![]() ![]() It has been the goal of transit planners, especially those in Virginia, to offer more service like the S-Bahn than Commuter Rail. We provide sales and leasing services for office, retail, industrial properites, investment brokerage services, site and land acquisition services. Not all, or even most, rail systems in the US operate like the VRE but more offer service closer to that model, catering more to the 9-5, weekday, car-owning office worker than to the 24/7, 365 resident who wants to travel downtown or across the region. Bahn Commercial Real Estate Services, a full service commercial real estate company located in St. The VRE literally drives one direction in the morning, parks trains downtown for lunch, and then sends them all back out again in the afternoon whereas, Munich runs trains from end-to-end of the system all day. ![]() On the other hand, you have a Commuter Rail system like the Virginia Railway Express (VRE) that offers workday, rush-hour only, unidirectional service into Washington, DC. On one hand you have an S-Bahn like Munich that offers regular, frequent, all-day, bidirectional service from regional hubs surrounding a city directly into Munich's central core. He began taking adult education classes to study English and frequently bought food from a catering truck before and after class. In the future, new insight into the cause of these conditions will aid in the development of other new approaches to therapy.I think it is important to look at S-Bahn service and Commuter Rail service as ends of a spectrum of rail service that serves a wider, suburban region around a city. If this medication is proven effective in the treatment of Graves' ophthalmopathy, it will likely become a mainstay of therapy for this difficult-to-treat condition. Bahn's research into the causes of GO and Graves' hyperthyroidism has led to a clinical trial of rituximab as a new therapy for GO. In the future, clinical trials will be performed to determine whether these small molecules might be used as therapy for Graves' hyperthyroidism and Graves' ophthalmopathy.ĭr. This turns off the receptor and prevents TSHR autoantibodies from affecting these cells. Bahn's laboratory team is studying a novel small molecule that attaches to the TSHR receptor on thyroid cells and also on fibroblasts from behind the eye. What new therapies are being developed to treat Graves' hyperthyroidism and GO? Dr.The changes in the tissues behind the eye result in the clinical features of GO including forward protrusion of the eyeball, enlargement of the eye muscles, and swelling of the eyelids and tissues. These same antibodies target TSHR on fibroblasts behind the eye and cause them to turn into fat cells and produce hyaluronic acid, a substance found in abundance in the orbits of patients with GO. These antibodies attach to this receptor found on thyroid cells and stimulate the cells to secrete too much thyroid hormone, a condition called hyperthyroidism. What causes GO, the eye condition found in patients with Graves' disease? Antibodies targeting the TSHR are found in the blood of patients with Graves' disease and GO.Bahn's research is funded by the National Institutes of Health and Mayo Clinic. ![]() Studies are under way to understand interactions between these cells and antibodies that target the thyroid-stimulating hormone receptor (TSHR) found on these cells.ĭr. Her team is studying the unique features of these cells that render them particularly susceptible to autoimmune attack. Bahn's laboratory is interested in the mechanisms and consequences of immune system activation of fibroblasts from behind the eye, the target cells involved in GO. The long-term goal of her laboratory team is to develop effective new therapies for the treatment and prevention of these conditions.ĭr. Bahn, M.D., studies the causes of Graves' ophthalmopathy (GO), Graves' hyperthyroidism and other autoimmune thyroid diseases. ![]()
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